TY - JOUR TI - Disentangling the relationship between tumor genetic programs and immune responsiveness AU - Bedognetti, Davide AU - Hendrickx, Wouter AU - Ceccarelli, Michele AU - Miller, Lance D. AU - Seliger, Barbara T2 - Current Opinion in Immunology AB - Correlative studies in humans have demonstrated that an active immune microenvironment characterized by the presence of a T-helper 1 immune response typifies a tumor phenotype associated with better outcome and increased responsiveness to immune manipulation. This phenotype also signifies the counter activation of immune-regulatory mechanisms. Variables modulating the development of an effective anti-tumor immune response are increasingly scrutinized as potential therapeutic targets. Genetic alterations of cancer cells that functionally influence intratumoral immune response include mutational load, specific mutations of genes involved in oncogenic pathways and copy number aberrations involving chemokine and cytokine genes. Inhibiting oncogenic pathways that prevent the development of the immune-favorable cancer phenotype may complement modern immunotherapeutic approaches. DA - 2016/04// PY - 2016 DO - 10.1016/j.coi.2016.02.001 DP - PubMed VL - 39 SP - 150 EP - 158 J2 - Curr. Opin. Immunol. LA - ENG SN - 1879-0372 ER -